What are the causes of benign prostate hyperplasia?

  • Androgens: Androgens and male sexual hormones (testosterone and dihydrotestosterone) are necessary for the development of BPH.Patients that have been castrated before puberty or those with genetic disorders in whom androgens either cannot be produced or function improperly do not develop BPH.
  • Familiar and genetic factors: It is known that BPH has a hereditary component (autosomal dominant) in 50% of men treated surgically for BPH before the age of 60.In contrast, only 9% of those treated after age 60 have a hereditary factor.